SERPINH1 and esophageal squamous cell carcinoma: To conclude, our study first demonstrated that SERPINH1 acted as an oncogene that controlled malignant phenotypes of ESCC cells, and the mechanism was elucidated at cellular level that miR-29c-3p repressed angiogenesis in ESCC targeting SERPINH1 to inactivate the Wnt signaling pathway.