Compared with participants with 1 paradoxical eczema event, TNF inhibitors were the most used biologics for the index event in the multiple-event cohort (16 [80%] vs 111 [50%]) followed by IL-17 inhibitors (2 [10%] vs 41 [19%]), IL-12/23 inhibitors (2 [10%] vs 63 [28%]), and IL-23 inhibitors (0 [0%] vs 6 [3%]) (eTable 5 in Supplement 1). This evidence concerns the gene IL17A and Eczematoid dermatitis.