There was found to be significant differences between the SYNGAP1-ID group and the typically developing controls on all four DSM-5 subscales (Inattention U = 12.5, p < 0.001; Hyperactivity U = 38, p < 0.001; Conduct disorder U = 47, p < 0.001; Oppositional defiant disorder U = 57 p = 0.001) (Fig. 3B). Here, SYNGAP1 is linked to Oppositional defiant disorder.