Thus, TGFβ1 could play dual roles in lymph metastasis by (i) inducing EMT and thereby providing tumor cells with invasive properties and capabilities to migrate towards chemotactic cues in the tumor microenvironment and (ii) stimulating lymphatic endothelial cells to produce chemotactic factors, which favors chemotactic migration towards the lymphatics. The gene discussed is TGFB1; the disease is neoplasm.