To investigate whether a combined treatment of EZH2 and FGFR inhibition is effective, we made use of mouse mesothelioma cell lines derived from our genetically defined BNC (Bap1−/−, Nf2−/−, Cdkn2ab−/−) and NC (Nf2−/−, Cdkn2ab−/−) mice (23). Here, NF2 is linked to mesothelioma.