The genomic landscape of malignant mesothelioma shows frequent inactivation of the CDKN2AB locus that encodes for p16INK4A, p15INK4B, and p14ARF cell-cycle inhibitor proteins and the neurofibromatosis type 2 (NF2) tumor suppressor gene (12–15). Here, CDKN2A is linked to malignant mesothelioma.