TGFβ is the main regulator of extracellular matrix accumulation and a potential key driver of hepatitis to liver fibrosis, TGF-β1 is the most effective cytokine to promote liver fibrosis, can inhibit the proliferation of hepatocytes, stimulate the activation of hepatic stellate cells (HSCs), promote the production of ECM, and regulate apoptosis of hepatocytes [180]. The gene discussed is TGFB1; the disease is hepatitis A virus infection.