In a study based on the Type 2 diabetes mellitus (T2DM) rat diabetic liver injury and neonatal rat cardiomyocyte injury model, a mouse heart failure model, Astragalus polysaccharide and Astragaloside IV were found to restore normal autophagy through the AMPK/mTOR pathway [37]. The gene discussed is MTOR; the disease is type 2 diabetes mellitus.