In studies based on LPS-induced neuroinflammation/microglia activation in mice and carbon tetrachloride-induced liver fibrosis in mice, chaihu saponin D suppressed inflammatory responses by regulating the NF-κB/TLR4 signaling pathway, and by inhibiting NLRP3 inflammatory vesicle expression [153–156]. Here, NFKB1 is linked to Hepatic fibrosis.