The results manifested that TUSC7 could promote oxidative stress by inhibiting miR-23b, thereby contributing to M2 polarization of macrophages through the SH2 domain-containing tyrosine phosphatase-2 (SHP2)-signal transducer and activator of transcription 3 (STAT3)-STAT6 axis and suppressing proliferation, migration and invasion of CRC cells. Here, STAT3 is linked to colorectal carcinoma.