It can be seen that TUSC7 can not only enhance the oxidative stress and SHP2 phosphorylation in CRC but also increase the expressions of IL-4 and IL-10, promote the M2 polarization of macrophages and suppress the expressions of MMP2 and MMP9 through mediating the STAT3/STAT6 signaling pathway. This evidence concerns the gene PTPN11 and colorectal carcinoma.