NLRP3 and acute respiratory distress syndrome: The NLRP3, caspase-1, and GSDMD N/GSDMD FL levels in ALI mice were sharply increased, then signally reduced by 3 mg/kg and 6 mg/kg HNG (Figure 6A–6D), indicating a repressive effect of HNG on NLRP3 signaling in ALI mice.