NLRP3 and coronary artery disorder: Furthermore, both NLRP3 inflammasome and IL-1β expression levels were upregulated among PA-exposed HUVECs, and these levels decreased after Metrnl co-treatment, further validating the link between increased ROS, NLRP3 activity, and inflammatory cytokine production, all of which have been associated with lowered functional capabilities in CAD.