NLRP3 and coronary artery disorder: The precise nature of the interactions between Metrnl and these pro-CAD factors, however, are still largely unknown, though a connection between exercise, Metrnl, and inhibition of NLR family pyrin domain containing 3 (NLRP3) inflammasome activity have been documented in a recent investigation [21], which could serve as a possible mechanistic basis behind the alleviative effects of Metrnl on CAD.