Polymorphisms in Vav have been associated with a number of diseases such as cardiovascular disease for Vav2 and Vav3 (56), inflammatory-associated diseases such as Rheumatoid Arthritis for Vav1 (57) and C-type lectin receptor-mediated responses and susceptibility to Candida albicans infection with Vav3 polymorphisms (58). Here, VAV2 is linked to rheumatoid arthritis.