For instance, it has been reported that yes‐associated protein (YAP)‐transcriptional coactivator with PDZ‐binding motif (TAZ) transcriptional activity is able to inhibit the pro‐inflammatory cyclic GMP–AMP synthase (cGAS)‐STING pathway, thus contributing to immune system suppression and tumor establishment.[99] The desmoplastic ECM can also create a biochemical barrier by interfering with signaling pathways, which lowers the immune surveillance at the TME. The gene discussed is CGAS; the disease is neoplasm.