At later stages of tumor development, the excessive remodeling of desmoplastic ECM promotes cancer progression through diverse signaling pathways, including and nonrestricted to TGF‐β, Wnt‐β‐catenin, and Notch, that lead to EMT and fuel metastasis (Figure 7A‐5).[102] In addition, the nature of the ECM at the primary and metastatic tumor sites is comparable. The gene discussed is TGFB1; the disease is cancer.