Consistent with a cardiomyopathy phenotype being present in these mice with diabetes, we observed significant reductions in the expression of Atp2a2 (SERCA2) (Figure 4b), and significant or strong trends for changes in other classic cardiac stress and contractile genes including Nppa (ANP) (WT: p < 0.05, KO: p = 0.12) (Figure 4c), Nppb (BNP) (WT: p < 0.05) (Figure 4d), Myh6 (WT and KO: p < 0.05) (Figure 4e), and Myh7 (WT: p < 0.05, KO: p = 0.08) (Figure 4f). This evidence concerns the gene NPPA and diabetes mellitus.