To establish whether TMEM14A also plays a role in the development of proteinuria in human disease, glomerular TMEM14A protein expression was examined in human kidney biopsies from patients with IgA nephropathy (IgAN), lupus nephritis (LN), minimal change disease (MCD), or diabetic nephropathy (DN). This evidence concerns the gene TMEM14A and IgA glomerulonephritis.