For instance, mutations such as (m.11778G>A/MT-ND4 & m.4216T>C/MT-ND1), and (m.14484T>C/MT-ND6 & m.13708 G>A/MT-ND5) have been found to contribute to the development of LHON in the J haplogroup (Torroni et al., 1997[30]). This evidence concerns the gene MT-ND5 and Leber hereditary optic neuropathy.