In addition, the mutations found in nuclear genes such as NDUFS2, OPA1, NDUFS7, MTFMT, PDSS1, NDUFV1, NDUFA3, DNAJC30, SLC25A46, SLC25A3 and MYOC extend our understanding of the genetic landscape of LHON. The gene discussed is PDSS1; the disease is Leber hereditary optic neuropathy.