In addition, the mutations found in nuclear genes such as NDUFS2, OPA1, NDUFS7, MTFMT, PDSS1, NDUFV1, NDUFA3, DNAJC30, SLC25A46, SLC25A3 and MYOC extend our understanding of the genetic landscape of LHON. Here, MYOC is linked to Leber hereditary optic neuropathy.