In addition, the mutations found in nuclear genes such as NDUFS2, OPA1, NDUFS7, MTFMT, PDSS1, NDUFV1, NDUFA3, DNAJC30, SLC25A46, SLC25A3 and MYOC extend our understanding of the genetic landscape of LHON. This evidence concerns the gene NDUFS2 and Leber hereditary optic neuropathy.