In LPS-induced AKI, the expression of pyruvate kinase muscle isoform 2 (PKM2), a critical enzyme responsible for catalyzing the last step of glycolysis, is significantly increased, and PKM2 can directly stimulate HIF-1α transactivation (Luo et al., 2011), indicating that PKM2 can regulate PDKs and LDH to promote lactate generation by activating HIF-1α. The gene discussed is HIF1A; the disease is acute kidney injury.