Glucose-insulin infusion can reduce renal injury induced by severe I/R in mouse experimental models (Melo et al., 2010), and clinical studies have shown that insulin sensitizing agents can improve AKI (Hu et al., 2012), and intensive insulin therapy for tight control of blood glucose can reduce the incidence of AKI in diabetic patients and critically ill patients (Schetz et al., 2008). This evidence concerns the gene INS and acute kidney injury.