In painless neuropathy, more irregular shaped arterioles were seen (Figure 3L, M); CD31-positive endothelial cells in contact with the lumen of BVs displayed some irregular projections (Figure 3L); furthermore, some regions of the lining cells were close together and linked by junctions, while others were separated from each other (arrow in Figure 3L). Here, PECAM1 is linked to neuropathy.