ORAI1 and acute pancreatitis: By crossing Orai1f/f mice with a pancreas-specific Cre line (Pdx1-Cre), pancreas-specific Orai1 deficient (Orai1ΔPdx1) mice were created.8 Acute pancreatitis was induced by hyperstimulation of cholecystokinin (CCK) receptors on the acinar cells by the frog peptide caerulein (a CCK analogue) or retrograde biliopancreatic duct infusion of sodium taurocholate.