Another NR patient, a male, 37 years old, M4, with TET2, ASXL1 and U2AF1 mutations, VAF values of 50.95%, 35.78% and 42.47%, respectively, and positive MLL/MLL fusion gene, PR after the 1st course of VEN-DHAG, NR after the 2nd course of VEN-AZA-CAG, and still NR after the 3rd course of adjustment to VEN-DCAG, finally exhibited disease progression, multiple organ failure and death. Here, KMT2A is linked to Multiple Organ Failure.