In addition, gene duplication/amplification at 7p11.2 activates EGFR expression through the formation of new topological associating domain (TAD) and the emergence of new enhancer-promoter interactions between LINC01446 and EGFR, and EGFR amplification and/or mutations are directly associated with poor prognosis of gliomas (Yang et al., 2022). This evidence concerns the gene EGFR and central nervous system cancer.