ATP5PF and type 2 diabetes mellitus: LncRNAs regulated by metformin potentially affect mitochondrial function; clinical research on DNA methylation in plasma from metformin-treated patients with T2DM showed that 57 lncRNA-associated DNA methylation regions were found, which included the mitochondrial ATP synthase-coupling factor 6 (ATP5J) (Solomon et al., 2020), suggesting that metformin may regulate ATP5J through lncRNAs.