GSDMD and periodontitis: Furthermore, metformin significantly alleviated NLRP3 and GSDMD expressions in diabetic periodontitis mice with a severe inflammation state, and in this study, lncRNA_1810058I24Rik, lncRNA_Gm12474, and lncRNA_Gm41514 were found to be co-expressed with NLRP3 and GSDMD (Zhou et al., 2020), which may potentially be regulated by metformin.