ABCC4 and Cholestatic liver disease: A major alteration found in the present work is the substantial increase in glucuronides in the blood of cirrhotic mice, which is explained by high levels of the sinusoidal export carriers Abcc3 and Abcc4 that are known to be upregulated in cholestatic liver disease and act by exporting bile acids from hepatocytes to avoid an increase beyond cytotoxic levels (Vartak et al., 2016; Jansen et al., 2017; Ghallab et al., 2019b).