TNF and neoplasm: Although the treatment efficiency was moderate, the ascites derived‐sEVs showed significant expression of the tumor‐specific antigens and strongly induced tumor‐specific antitumor cytotoxic T cells response,80, 81 which was in consistent with our results, that compared with O‐sEVs, T‐sEVs enriched cargoes promoting cytotoxic immunity and enhancing the IFN‐γ and TNF‐α production by CD8+ T cells.