According to KEGG pathway enrichment analysis, up-regulated DEGs were mainly enriched in cell cycle, progesterone-mediated oocyte maturation, p53 signaling pathway, cellular senescence, oocyte meiosis (Figure 4A), while the down-regulated DEGs were significantly enriched in PI3K-Akt signaling pathway, focal adhesion, Ras signaling pathway, Alcoholic liver disease, EGFR tyrosine kinase inhibitor resistance (Figure 4B). This evidence concerns the gene TP53 and alcoholic liver diseases.