Up-regulated and down-regulated DEGs were significantly enriched in cell cycle, PI3K-Akt signaling pathway, progesterone-mediated oocyte maturation, p53 signaling pathway, cellular senescence, oocyte meiosis, melanoma, FoxO signaling pathway, AMPK signaling pathway, EGFR tyrosine kinase inhibitor resistance, fatty acid degradation, antifolate resistance (Figure 3D). This evidence concerns the gene TP53 and melanoma.