While, the expression of ASS1 in the tumor tissues of BRCA, CHOL (Cholangiocarcinoma), KICH (Kidney Chromophobe), KIRC, KIRP (Kidney renal papillary cell carcinoma), LIHC, PRAD (Prostate adenocarcinoma) (p<0.001 for the above tumors), GBM, PCPG (Pheochromocytoma and paraganglioma), UCEC (p<0.01 for the above tumors), and BLCA (Bladder urothelial carcinoma) (p<0.05) is lower than the corresponding normal tissues. The gene discussed is ASS1; the disease is hereditary pheochromocytoma-paraganglioma.