ASS1 and colon adenocarcinoma: We can also observe that Q138Rfs*2/Pfs*12 alteration was detected in cases of STAD, BRAC (Breast invasive carcinoma), and COAD, which could induce a frameshift mutation of the ASS1 gene, translation from Q (Glutarnine) to R (Arginine) or P (Proline) at the 138 locus of ASS1 protein.