To better characterize the effect of the individual (anti-PD-1, AdV5/3-D24-ICOSL-CD40L) and combinatorial (AdV5/3-D24-ICOSL-CD40L + anti-PD-1) therapies, we performed gene expression analysis by RNA-seq on extracted human H226 mesothelioma xenografts explanted from the humanized mice. This evidence concerns the gene ICOSLG and mesothelioma.