The present study aimed to determine HIF1A mRNA expression, the protein expression of HIF-1α and VEGF-A in the three most common histological types of renal cancer – ccRCC, pRCC, chRCC, as well as to analyze HIF1A and VEGFA differential gene expression and its influence on patient’s survival. Here, HIF1A is linked to nonpapillary renal cell carcinoma.