Although cerebral oxidative damage is a part of aging and neurodegenerative diseases, OS and inflammatory processes are also environmentally driven risk factors that were found to interact with apolipoprotein E (ApoE)-encoding, the APOE-gene that plays a significant role in the neuropathology course of AD and leads to a susceptibility of AD development and progression74. The gene discussed is APOE; the disease is neurodegenerative disease.