MAPT and Alzheimer disease: The condition of tau hyperphosphorylation caused by indirect events (Aβ mediated neurotoxicity, OS, and chronic inflammation) as in AD, and the direct events (aberrant activation of tau kinases, downregulation of phosphatases, mutations, and covalent modifications of tau), will cause a loss of binding between MAP tau and MTs and trigger the formation of NFTs aggregation composed of misfolded tau protein deposits in neurons or glia cells, also called tauopathies, that would cause neurotoxicity and compromised axonal transport69,71–73.