The role of BDNF in neurogenesis and synaptic plasticity also illustrates the susceptibility that arises when the production of mBDNF in carrying out its functions is inadequate, and this is reflected in a significant decrease in BDNF levels in neurological diseases such as AD and other types of dementia, Parkinson’s disease, epilepsy, Huntington’s disease, as well as neurobehavior disorders such as schizophrenia, autism, depression, and social avoidance84,89,90. Here, BDNF is linked to juvenile Huntington disease.