N-163 strain produced beta-glucan has been shown to regulate inflammatory markers and immunity, namely IL-6, C-reactive protein (CRP), D-Dimer, ferritin, neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-C-reactive protein ratio (LCR), leucocyte-to-C-reactive protein ratio (LeCR), and leukocyte-to-IL-6 ratio (LeIR) in previous pre-clinical and clinical studies of diabetes, Non-alcoholic steatohepatosis (NASH) and COVID-19 (Ikewaki et al., 2021, Ikewaki et al., 2022, Ikewaki et al., 2022 Nov-Dec, Raghavan et al., 2022a). The gene discussed is CRP; the disease is COVID-19.