Zhang et al13found that, by injecting superoxide dismutase 2 (SOD2) and gene therapy in mice, when SOD2 is overexpressed, it can counteract the effects of noise and ototoxic drugs and improve the symptoms of HL, and PI3K and MAPK signaling pathways are also affected by SOD2, indicating that modulating PI3K and MAPK signaling pathways may have some therapeutic effects on HL. Here, SOD2 is linked to Hodgkins lymphoma.