Additionally, infections with bacteria, such as Streptococcus pyogenes (Diao and Kohanawa, 2005), Streptococcus pneumoniae (van der Poll et al., 1997), M. tuberculosis (Ladel et al., 1997), and T. cruzi (Sanmarco et al., 2017), were more severe in IL-6−/− mice at similar inoculation titers than WT mice. Here, IL6 is linked to infection.