CGRP also shares similarities with PACAP in terms of functions; CGRP has been shown to play an important role in the regulation of stress and anxiety-like behaviors, physical and emotional pain responses, migraine, and taste aversion (Kocorowski and Helmstetter, 2001; Campos et al., 2018; Chen et al., 2018). This evidence concerns the gene ADCYAP1 and migraine disorder.