CHI3L1 and Sepsis: Chitinase-3 like-protein-1 (CHI3L1, other name YKL-40) may be another important protein molecule involved in the pathological process of RA and sepsis.YKL-40 is synthesized and secreted by a wide variety of cells including macrophages, neutrophils, and chondrocytes and plays an important role in tissue injury, inflammation, tissue repair and remodeling responses [68].