As shown in Fig. 6A, B, we found that the expression of SNAP25 decreased both in the OB and OE of AD+ mice compared to AD− mice (in OB, 0.30 ± 0.21, P < 0.0001; in OE, 0.46 ± 0.28, P = 0.0001). The gene discussed is SNAP25; the disease is Alzheimer disease.