Similarly, we also found that the expression level of all the hub genes was more significantly decreased in PD+ mice (SNAP25, 0.56 ± 0.25, P = 0.0004; SYN1, 0.85 ± 0.10, P = 0.0010; SYT1, 0.71 ± 0.28, P = 0.0166; GAP43, 0.62 ± 0.25, P = 0.0010; SNAP91, 0.68 ± 0.33, P = 0.0210, Fig. 4F–J). The gene discussed is GAP43; the disease is Parkinson disease.