To determine the role of PSMD14 in osteosarcoma, we examined the expression of PSMD14 mRNA and protein in four human osteosarcoma cell lines (MG63, Saos-2, 143B, and U2OS) and two normal human osteoblasts (NHOst and hFOB 1.19). Here, PSMD14 is linked to osteosarcoma.