PSMD14 and osteosarcoma: In the present investigation, we discovered that PSMD14 might be an independent biomarker of poor prognosis in individuals with osteosarcoma, and interfering with PSMD14 affects the malignant phenotype of osteosarcoma cells in vitro, including apoptosis, proliferation, invasion, and migration, as well as the growth of cell grafts in vivo.