As indicated in Table 1, increased PSMD14 expression in tumor tissues was positively associated with the advanced clinical stage and pathological grade, and the univariate and multivariate logistic regression analysis demonstrated that PSMD14 overexpression served as an independent predictor of 5-year survival in patients with osteosarcoma (Tables 2 and 3). The gene discussed is PSMD14; the disease is osteosarcoma.