ACVR1 and colorectal cancer: Seo et al. [21] discovered that PSMD14 could be regarded as a positive regulator that can activate the BMP6 signaling pathway and increase the stability of ALK2 via deubiquitination of the K48-linked ALK2 type I receptor, which significantly enhances tumorigenesis of colorectal cancer cells and cancer stemness/chemoresistance.