Jing et al. [10] showed that PSMD14 can improve E2F1 stability by blocking E2F1 ubiquitination in head and neck squamous cell carcinoma, hence promoting cell proliferation, stemness, and chemoresistance by the E2F1/AKT/SOX2 pathway. The gene discussed is PSMD14; the disease is head and neck squamous cell carcinoma.