BRCA1 and triple-negative breast carcinoma: While WBC BRCA1 methylation has been associated with an elevated hazard ratio of triple-negative breast cancer, to this end, the quantitative contribution of normal tissue BRCA1 methylation to TNBC and, potentially, non-TNBC, has remained unknown due to lack of studies evaluating concordant BRCA1 methylation in tumor tissue and matched WBC.