IGHE and Airway obstruction: Prior to biologic therapy, the work-up revealed a lack of symptom control (mean ACT 13), marked airway obstruction (mean FEV1%predicted 58.25%), intermediate to high levels of inflammation (mean total IgE 523.9uL/mL,max 5000uL/mL;mean FeNO26.35 ppb, max 119 ppb; mean blood eosinophilscount499.9 cells/microL, max 3460 cells/microL.