CFTR and cystic fibrosis: Hartmut G et al. showed that treatment with Ivacaftor increased NO formation in the airways of CF patients (P-value = 0.002) [37], while Dornase alpha or hypertonic saline had no effect on NO formation.In this study [37, 38], Ivacaftor was used as a drug that targets CFTR, which could lead to increase NO formation in the airways of these patients.