AFP and neoplasm: To this end, we conducted a large-scale retrospective study involving a multicenter cohort of 2770 patients, with the aim of exploring the value of CRP and AFP in the prognostic evaluation of HCC after resection, and constructed a PACE risk score (Prognostic implications of AFP and CRP Elevation), with the goal of providing clinicians with additional information on tumor biological aggressiveness and systemic inflammatory response.