There were significant differences in age; years of education; CRP, C3, and C4 levels; and the MoCA and MMSE scores between the two groups (P < 0.05); however, there was no significant differences in gender, hypertension history, diabetes, and cardiovascular disease, total dialysate glucose content, and use of blood pressure medications (P > 0.05). The gene discussed is CRP; the disease is Hypertension.