Furthermore, we found enrichment of DNAase I hypersensitive sites and of specific transcription factor motifs in adolescents at RAR, ESRRA, V LXR and CTCF (Supplementary File, Fig. 7) regulating genes which play roles in cell differentiation, proliferation, have neuroprotective actions and regulate cholesterol metabolism, inflammation, autoimmunity, and cancer [34, 35]. The gene discussed is ESRRA; the disease is cancer.