MAPT and early-onset autosomal dominant Alzheimer disease: Worsening global cognition has also been linked with reduced spindle duration [76], and a reduction in spindle density has been correlated with cerebrospinal fluid levels of amyloid-beta 42 (Aβ42), phosphorylated tau (p-Tau), and total-tau (T-Tau) markers of Alzheimer’s disease pathology [77].