IGF2BP2 and familial dilated cardiomyopathy: In accordance with the proteomics and myofibril staining data, the sarcomeres of the tTA-IGF2BP2 heart showed an altered structure, with the distance between the Z lines elongated (sarcomere length) and the width of the myofibrils shortened (Fig. 6b, c), a phenotype observed in dilated cardiomyopathy (DCM)29,30.