IGF2BP2 and dilated cardiomyopathy: To elucidate the underlying mechanisms through which IGF2BP2 helps mediate dilated cardiomyopathies, we prepared protein extracts from hearts expressing either the IGF2BP2 transgene or the Tet transactivator alone for 15 days and analyzed them by mass spectrometry (MS; Supplementary Fig. 3a, b; Supplementary Data 1).