IGF2BP2 and heart disorder: Increasing the overexpression period by only two days (16 as opposed to 14 days) caused a significant change in the phenotype of the mice: two mice died within 2 weeks of turning off hIGF2BP2, one mouse survived until the end of the experiment (12 weeks) but had an enlarged, malfunctioning heart, and only two mice were healthy 3 months post-abrogation of hIGF2BP2. These results indicate that, in mice, IGF2BP2 upregulation triggers a spiral into cardiac disease that is initially reversible but becomes independent of IGF2BP2 expression after 2 weeks.