We did not find evidence for an association between genetically predicted fetuin-A and any stroke (OR = 0.95, 95% CI 0.77–1.17, P = 0.63), and ischemic stroke (OR = 1.00, 95% CI 0.70–1.42, P = 0.99) in the main IVW-MRE analyses (Fig. 1a). Here, AHSG is linked to ischemic stroke.