One possible explanation of the discrepancy of these results is a larger strength of the genetic instruments in the current study, as we find that using the effect sizes of the genetic variants on fetuin-A obtained from the Potsdam part of the EPIC-InterAct study10 instead of those from the CHARGE meta-analysis11 nullifies the association between fetuin-A and type 2 diabetes. This evidence concerns the gene AHSG and type 2 diabetes mellitus.