However, we did find that one SD increase in genetically predicted fetuin-A increased risk of type 2 diabetes (OR = 1.21, 95% CI 1.13–1.30, P =  < 0.01), which was further supported by sensitivity analyses (MR Lasso OR = 1.21, 95% CI 1.04–1.42, P = 0.02, weighted median OR = 1.22, 95% CI 1.03–1.45, P = 0.03, and MR contamination mixture model OR = 1.23, 95% CI 1.02–1.48, P = 0.04). This evidence concerns the gene AHSG and type 2 diabetes mellitus.