In this study, loss of IFNγR signaling emerged as a sensitizing pathway for CAR-T killing in an aggressive murine model of B-ALL, yet blockade of IFNγ cytokine by antibody did not enhance susceptibility to CAR-T cells, and, rather, resulted in abrogation of anti-tumor effects of CAR-T cells. The gene discussed is IFNG; the disease is precursor B-cell acute lymphoblastic leukemia.