For example, an in vitro genetic screen in a human glioblastoma line showed that loss of interferon-gamma receptor (IFNGR) mediated resistance to CAR-T therapy; this was validated in multiple solid tumor cell lines and xenograft models, and demonstrated that impaired IFNγR signaling didn’t have the same effect in lymphoid tumors25. Here, IFNGR1 is linked to glioblastoma.