The weekly percentage increase in AML cells in Prrx1-CreERT2;Mettl3fl/fl mice were greater than that in control mice (mean increase of 3.83% versus 1.25% from day 7 to day 14, and mean increase of 8.46% versus 1.32% from day 14 to day 17, respectively) (Supplementary Fig. S2C). Here, PRRX1 is linked to acute myeloid leukemia.