FCM analysis revealed a more rapid increase in the total engraftment of MLL-AF9 AML cells in the PB of Prrx1-CreERT2;Mettl3fl/fl mice compared to Mettl3fl/fl mice after transplantation (mean increase of 3.12% versus 2.09% from day 7 to day 14, and mean increase of 3.14% versus 1.95% from day 14 to day 21, respectively) (Fig. 2C). The gene discussed is KMT2A; the disease is acute myeloid leukemia.