Adipocytes secrete various factors, including leptin, platelet-derived growth factor, insulin-like growth factor 1, matrix metalloproteinase 11, interleukin 6, and stromal cell-derived factor 1 (SDF-1), and these are related to the AML cells migration, growth, and metastasis [46–48]. Here, MMP11 is linked to acute myeloid leukemia.