Using this method, genes with rare variants associated with PCa risk (family-wise error rate (FWER) < 0.05; Supplementary Fig. 13, Supplementary Data 7) included H3C1 (rs199943654, P = 9.91e−05), MBP (rs61742941, P = 1.23e−04), and MTG1 (3 variants including predicted deleterious variant (PDV) rs138851534, P = 1.59e−04). This evidence concerns the gene MBP and posterior cortical atrophy.