Notably and of relevance to this study, of the nine recently identified African-specific/predominant PCa risk variants identified, seven occurred in gene regions, including a protein truncating variant in the prostate-specific gene anoctamin 7 (ANO7 Ser914Ter), adding a third functionally relevant protein coding variant to the repertoire of known African-specific PCa risk alleles, including previously identified CHEK2 Ile448Ser18 and HOXB13 Ter285Lys19. This evidence concerns the gene ANO7 and posterior cortical atrophy.