We have reported that upregulated MIF through CD74 to activate ERK, mammalian target of rapamycin (mTOR) and Rb-E2F signaling to regulated cystic renal epithelial cell proliferation and to suppress p53 signaling dependent cystic renal epithelial cell apoptosis in autosomal dominant polycystic kidney disease (ADPKD) [9]. This evidence concerns the gene RB1 and autosomal dominant polycystic kidney disease.