According to TCGA, RPLP2 is significantly upregulated in HCC tissue (n = 369) compared to nontumor hepatic tissue (n = 160), and its overexpression is associated with poor liver cancer patient prognosis, as indicated by the low overall survival rate and disease-free survival rate among those with high RPLP2 expression (Fig. 1A). The gene discussed is RPLP2; the disease is hepatocellular carcinoma.