In patients with obesity, adipose tissue produces adipokines such as leptin, lipocalin, resistin and endolipoproteins, as well as inflammatory cytokines including tumor necrosis factor-alpha (TNF-α), interleukin 1 (IL-1) and interleukin 6 (IL-6)14–16. This evidence concerns the gene TNF and obesity due to melanocortin 4 receptor deficiency.