In addition, Xiao et al overexpressed Ubc9 in a model of acute myocardial hypoxia and ischemia and observed that overexpression of Ubc9 can promote cardiac autophagy by promoting the formation of autophagosomes and autolysosomes, significantly improving cardiac function after myocardial infarction and alleviating left ventricular pathological remodeling.55 Here, UBE2I is linked to myocardial infarction.